Week 1
| Mark Bulger (LVA) | 348 yards | vs. Madera Crusaders |
| David Carr (GSB) | 329 yards | vs. Golden State Bears |
| Carson Palmer (REE) | 315 yards | vs. Carolina Cobras |
| Chad Pennington (EIS) | 300 yards | vs. Toledo Rocks |
Week 2
| Philip Rivers (PEN) | 403 yards | vs. Golden State Bears |
| Mark Bulger (LVA) | 356 yards | vs. Salt Lake Knights |
Week 3
| Mark Bulger (LVA) | 402 yards | vs. Peninsula Ronin |
| Drew Brees (SLK) | 324 yards | vs. Carolina Cobras |
| Chad Pennington (EIS) | 306 yards | vs. Reese Restrictors |
Week 4
| Peyton Manning (ROS) | 436 yards | vs. Miami Storm |
| Tony Romo (GSB) | 357 yards | vs. Salt Lake Knights |
| Drew Brees (SLK) | 350 yards | vs. Golden State Bears |
| Carson Palmer (REE) | 325 yards | vs. Saginaw Fighting Squirrels |
| Mark Bulger (LVA) | 311 yards | vs. Yukon Jacks |
Week 5
| Carson Palmer (REE) | 378 yards | vs. Salt Lake Knights |
| Tom Brady (ARI) | 320 yards | vs. Peninsula Ronin |
Week 6
| Brett Favre (MAD) | 344 yards | vs. Golden State Bears |
| Tom Brady (ARI) | 305 yards | vs. Park Hill Atoms |
| Chad Pennington (EIS) | 300 yards | vs. Saginaw Fighting Squirrels |
Week 7
| Damon Huard (TOL) | 339 yards | vs. Park Hill Atoms |
| David Garrard (SAG) | 331 yards | vs. Austin Vipers |
| Mark Bulger (LVA) | 311 yards | vs. Edmonds Evolution |
Week 8
| Mark Bulger (LVA) | 391 yards | vs. Miami Storm |
| Jeff Garcia (BAY) | 385 yards | vs. Park Hill Atoms |
| Matt Hasselbeck (STL) | 382 yards | vs. Austin Vipers |
| Michael Vick (PHA) | 377 yards | vs. Bay City Blitz |
| Drew Brees (SLK) | 329 yards | vs. Madera Crusaders |
| Peyton Manning (ROS) | 320 yards | vs. Golden State Bears |
Week 9
| David Carr (GSB) | 393 yards | vs. Yukon Jacks |
| Alex Smith (MIA) | 343 yards | vs. Madera Crusaders |
| Peyton Manning (ROS) | 325 yards | vs. Edmonds Evolution |
Week 10
| Peyton Manning (ROS) | 349 yards | vs. Yukon Jacks |
| Eli Manning (TOL) | 324 yards | vs. Saginaw Fighting Squirrels |
| Drew Brees (SLK) | 321 yards | vs. Miami Storm |
Week 11
| Tom Brady (ARI) | 301 yards | vs. Park Hill Atoms |
Week 12
| Mark Bulger (LVA) | 505 yards | vs. Bay City Blitz |
| Jason Campbell (SAG) | 368 yards | vs. Salt Lake Knights |
Week 13
| Drew Brees (SLK) | 409 yards | vs. Madera Crusaders |
| David Carr (GSB) | 331 yards | vs. Eisenhower Hell-Cats |
Week 14
| Chad Pennington (EIS) | 353 yards | vs. Toledo Rocks |
Week 15
| Trent Green (EDM) | 429 yards | vs. Toledo Rocks |
| Drew Brees (SLK) | 404 yards | vs. Eisenhower Hell-Cats |
| Eki Manniung (TOL) | 329 yards | vs. Edmonds Evolution |
| David Carr (GSB) | 317 yards | vs. Carolina Cobras |
Week 16
| Trent Green (EDM) | 544 yards | vs. Madera Crusaders |
| Mark Bulger (LVA) | 393 yards | vs. Yukon Jacks |
| David Carr (GSB) | 357 yards | vs. Salt Lake Knights |
| Donovan McNabb (YUK) | 348 yards | vs. Las Vegas Aces |
| Drew Brees (SLK) | 310 yards | vs. Golden State Bears |